Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models

Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models

Ionic self-assembly of the peptide RADARADARADARADA (RADA16-1) may form a well-defined nanofiber and eventually a hydrogel scaffold, with a water content of over 99.5%. This leads to the establishment of a nanofiber barrier that can be used to achieve complete hemostasis in less than 20 s in multiple tissues and in a variety of different wounds. In the present study, the nanofiber scaffolds of ...

Molecular structure of RADA16-I designer self-assembling peptide nanofibers.

The designer self-assembling peptide RADA16-I forms nanofiber matrices which have shown great promise for regenerative medicine and three-dimensional cell culture. The RADA16-I amino acid sequence has a β-strand-promoting alternating hydrophobic/charged motif, but arrangement of β-strands into the nanofiber structure has not been previously determined. Here we present a structural model of RADA...

Dynamic reassembly of peptide RADA16 nanofiber scaffold.

Nanofiber structures of some peptides and proteins as biological materials have been studied extensively, but their molecular mechanism of self-assembly and reassembly still remains unclear. We report here the reassembly of an ionic self-complementary peptide RADARADARADARADA (RADA16-I) that forms a well defined nanofiber scaffold. The 16-residue peptide forms stable beta-sheet structure and un...

molecular mechanisms of methimazole cytotoxicity in isolated rat hepatocytes

on some bayesian statistical models in actuarial science with emphasis on claim count

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